癌症研究
转移
下调和上调
基因敲除
结直肠癌
连环素
EZH2型
上皮-间质转换
肿瘤进展
状态5
细胞生长
生物
交易激励
癌症
连环蛋白
医学
信号转导
Wnt信号通路
内科学
细胞培养
基因表达
细胞生物学
基因
生物化学
遗传学
作者
Yiwu Weng,Yang Yu,Linlin Ren,Yun Cui,Youyong Lü,Haoyan Chen,Xiong Ma,Wenxin Qin,Weibiao Cao,Jie Hong,Jing‐Yuan Fang
出处
期刊:Carcinogenesis
[Oxford University Press]
日期:2014-03-06
卷期号:35 (6): 1389-1398
被引量:12
标识
DOI:10.1093/carcin/bgu057
摘要
C9orf140 is a newly identified and characterized gene which is associated with cell proliferation and tumorigenicity. Expression of C9orf140 is upregulated in human gastric cancer and colorectal cancer (CRC); however, little is known about its role in CRC progression. We have investigated the clinical significance, biological effects and mechanisms of C9orf140 signaling. We found that the expression of C9orf140 is dramatically increased in a subset of CRC and correlates significantly with vascular invasion and lymph node metastasis. Our finding showed that knockdown of C9orf140 significantly reduced cell proliferation and invasion in vitro and dramatically increased overall survival and decreased lung metastasis in vivo. Conversely, overexpression of C9orf140 significantly increased lung metastasis and shortened overall survival when compared with control tumors. C9orf140-induced CRC cell invasion may depend on promoting the epithelial–mesenchymal transition progression. STAT5 may directly interact with the enhancer of zeste homolog 2 (EZH2) and β-catenin to enhance C9orf140 gene transactivation. Furthermore, C9orf140 may participate in cell invasion which is induced by STAT5, EZH2 or β-catenin activation. We describe the role of C9orf140 in CRC progression and find that C9orf140 overexpression may be regulated by STAT5, EZH2 and β-catenin interaction.
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