病毒学
生物
卡波西肉瘤相关疱疹病毒
病毒性表皮
衣壳
人类疱疹病毒
病毒
肉瘤
伽马赫氏病毒亚科
DNA
基因
疱疹病毒科
同源染色体
代表性差异分析
DNA测序
病毒性疾病
遗传学
病理
医学
基因表达
作者
Yuan Chang,Ethel Cesarman,Melissa S. Pessin,Frank Lee,Janice Culpepper,Daniel M. Knowles,Patrick S. Moore
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1994-12-16
卷期号:266 (5192): 1865-1869
被引量:5551
标识
DOI:10.1126/science.7997879
摘要
Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.
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