吉西他滨
前药
脱氧胞苷激酶
脱氧胞苷
核苷
药品
化学
医学
核苷类似物
药理学
化疗
癌症研究
生物化学
内科学
作者
Miao He,Xuehong Chen,Yepeng Luan
标识
DOI:10.2174/0929867326666190816230650
摘要
Gemcitabine as a pyrimidine nucleoside analog anticancer drug has high efficacy for a broad spectrum of solid tumors. Gemcitabine is activated within tumor cells by sequential phosphorylation carried out by deoxycytidine kinase to mono-, di-, and triphosphate nucleotides with the last one as the active form. But the instability, drug resistance and toxicity severely limited its utilization in clinics. In the field of medicinal chemistry, prodrugs have proven to be a very effective means for elevating drug stability and decrease undesirable side effects including the nucleoside anticancer drug such as gemcitabine. Many works have been accomplished in design and synthesis of gemcitabine prodrugs, majority of which were summarized in this review.
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