化学发光
二氧乙烷
半胱氨酸
脚手架
化学
纳米技术
组合化学
生物物理学
生物化学
生物医学工程
材料科学
医学
色谱法
生物
酶
作者
Jinyu Sun,Zhian Hu,Sichun Zhang,Xinrong Zhang
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2018-12-28
卷期号:4 (1): 87-92
被引量:43
标识
DOI:10.1021/acssensors.8b00936
摘要
A novel chemiluminescent probe for detection of cysteine (Cys) from other biothiols has been reported by utilizing the excellent chemiluminescent Schaap's adamantylidene-dioxetane scaffold. After careful assessment, the probe CL-Cys could detect Cys with high sensitivity and total light photons increased by 28-fold after the probe was treated with Cys, with the detection limit of 7.5 × 10–8 M. Finally, CL-Cys was further utilized for the chemiluminescent imaging of endogenous Cys in a living mouse. In general, this probe has a remarkable ability to detect Cys, which provides a valuable method for interrogation of the Cys roles in more biological and pathological processes.
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