氰化
化学
烷基
催化作用
镍
氰化物
有机化学
小学(天文学)
药物化学
天文
物理
作者
Aiyou Xia,Xin Xie,Haoyi Chen,Jidong Zhao,Chunli Zhang,Yuanhong Liu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2018-11-15
卷期号:20 (23): 7735-7739
被引量:33
标识
DOI:10.1021/acs.orglett.8b03539
摘要
A nickel-catalyzed cyanation of unactivated secondary alkyl chlorides or bromides using less toxic Zn(CN)2 as the cyanide source has been developed. The reaction features the use of air-stable and inexpensive NiCl2·6H2O or Ni(acac)2 as the precatalysts and offers an efficient synthesis of a broad range of alkyl nitriles. Cyanation of primary alkyl chlorides or bromides was also achieved by reaction with Zn(CN)2 in the presence of n-Bu4NCl without the need of nickel catalyst.
科研通智能强力驱动
Strongly Powered by AbleSci AI