雌激素
重性抑郁障碍
认知
心理学
脆弱性(计算)
社会心理的
萧条(经济学)
认知脆弱性
临床心理学
医学
神经科学
精神科
内科学
抑郁症状
经济
宏观经济学
计算机科学
计算机安全
作者
Kimberly Albert,Paul Newhouse
标识
DOI:10.1146/annurev-clinpsy-050718-095557
摘要
This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. We propose a model of estrogen effects on multiple brain systems that interface with stress-related emotional and cognitive processes implicated in MDD and discuss possible mechanisms through which reproductive events and changes in estrogen may contribute to MDD risk in women with other concurrent risk factors.
科研通智能强力驱动
Strongly Powered by AbleSci AI