Synthesis of 2‐Acyl‐Substituted Pyrazine Derivatives through Silver‐Catalyzed Decarboxylative Coupling Reactions

Abstract An efficient regioselective acylation reaction of pyrazine with α‐oxocarboxylic acid via silver catalysis has been developed. The desired acyl substituted pyrazine derivatives were isolated in up to 97% yields and features a very broad substrate scope. Thermogravimetric analysis of particular product 3 o indicated that its fracture temperature was about 248 °C.