脂筏
膜
离子通道
木筏
细胞生物学
膜蛋白
生物物理学
化学
脂质微区
转运蛋白
生物
生物化学
受体
有机化学
共聚物
聚合物
作者
Alessandro Pristerà,Kenji Okuse
标识
DOI:10.1177/1073858410393977
摘要
Multiple plasma membrane proteins such as ion transporters and ion channels are involved in electrogenesis by setting resting membrane potentials and triggering/propagating action potentials. Recent findings strongly suggest that some of these membrane proteins are selectively transported into membrane microdomains termed lipid rafts. There appear to be multiple mechanisms for the specific protein translocation to lipid rafts, and many of these proteins exhibit distinct properties when inserted into the raft microdomains. Here the authors review the plasma membrane ion channels specifically localized at membrane lipid rafts in neurons. The mechanisms to selectively translocate these molecules to the lipid rafts and the consequences of the trafficking are also discussed.
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