The characteristic of osteoarthritis (OA) is the loss of articular cartilage.This loss arises from an imbalance between cartilage synthesis and degradation.The cartilage collagens were important components of cartilage.It's alteration in metabolism and structure will make an effective influence on occurrence,development and prognosis of osteoarthritis.This article will summarize the relationship between the markers of cartilage collagens and osteoarthritis.