Objective To study the chemical constituents from the sporophore of Hericium coralloides.Methods The chemical constituents were separated and purified by chromatographic methods after solvent extraction and were identified by spectroscopic analyses(MS and NMR).Results Twelve compounds were isolated from PE and CHCl3fractions in the sporophore of H.coralloides and were identified as 9,12-octadecadienoic acid methyl ester(1),ergosta-7,22-dien-3β-yl palmitate(2),ergosta-4,6,8(14),22-tetraen-3-one(3),ergosterol peroxide(4),ergosterol(5),ergosta-7,22-dien-3β-ol(6),hericenone J(7),cerevisterol(8),ergosta-7,22-dien-3-one(9),β-sitosterol(10),hericene A(11),and hericene C(12).Conclusion All of these compounds are separated from the sporophore of H.coralloides for the first time.