Heterocyclic Bridgehead Nitrogen Atom System: Review on [1,2,4] Triazolo[3,4-b] [1,3,4] thiadiazole and Its Pharmacological Screening.

There has been considerable interest in the development of novel anticonvulsant compounds, , analgesic, anti-inflammatory, antimicrobial, antimycobacterial, antitumour, and antitubercular activities. 1,3,4-thiadiazole constitute Significant class of compounds for new drugs development. They Have an interesting pharmacophore displaying a wide range of pharmacological activity. The 1,3,4-thiadiazole compound is an interesting heterocycle. A group that was used to synthesise a variety of useful bioactive compounds. The stability of the thiadiazole nucleus has inspired the medicinal chemist to perform various structural variations in the ring. Marketed drugs such as acetazolamide and methazolamide have shown their therapeutic potential Therefore, many researchers have identified these compounds as target structures and evaluated their biological activities. This review highlights the different pharmacological activities associated with the 1,3,4-thiadiazole ring system.