自愈水凝胶
纳米技术
化学
再生医学
细胞外基质
药物输送
生化工程
材料科学
生物化学
工程类
有机化学
细胞
作者
Kunyu Zhang,Qian Feng,Zhiwei Fang,Luo Gu,Liming Bian
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2021-06-30
卷期号:121 (18): 11149-11193
被引量:211
标识
DOI:10.1021/acs.chemrev.1c00071
摘要
Owing to their unique chemical and physical properties, hydrogels are attracting increasing attention in both basic and translational biomedical studies. Although the classical hydrogels with static networks have been widely reported for decades, a growing number of recent studies have shown that structurally dynamic hydrogels can better mimic the dynamics and functions of natural extracellular matrix (ECM) in soft tissues. These synthetic materials with defined compositions can recapitulate key chemical and biophysical properties of living tissues, providing an important means to understanding the mechanisms by which cells sense and remodel their surrounding microenvironments. This review begins with the overall expectation and design principles of dynamic hydrogels. We then highlight recent progress in the fabrication strategies of dynamic hydrogels including both degradation-dependent and degradation-independent approaches, followed by their unique properties and use in biomedical applications such as regenerative medicine, drug delivery, and 3D culture. Finally, challenges and emerging trends in the development and application of dynamic hydrogels are discussed.
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