甲磺酸
化学
卤化物
醋酸
烷基
产量(工程)
试剂
盐(化学)
溶剂
有机化学
冶金
材料科学
作者
Xavier Bertrand,Pascal Paquin,Laurent Chabaud,Jean‐François Paquin
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2021-11-22
卷期号:54 (05): 1413-1421
被引量:6
标识
DOI:10.1055/s-0040-1719856
摘要
Abstract The hydrochlorination, hydrobromination, and hydroiodination of unactivated alkenes using methanesulfonic acid and inorganic halide salts (CaCl2, LiBr, LiI) in acetic acid are reported. This approach uses readily available and inexpensive reagents to provide the alkyl halides in up to 99% yield. An example of deuteriochlorination using deuterated acetic acid as the solvent is also demonstrated.
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