Genotoxicity evaluation of silica nanoparticles in murine: a systematic review and meta-analysis

遗传毒性 彗星试验 体内 DNA损伤 体外 微核 化学 分子生物学 毒性 微核试验 药理学 毒理 生物 DNA 生物化学 遗传学 有机化学
作者
Li Li,Yaxin Deng,Xiaojia Meng,Hongmei Chang,Chunmei Ling,Danni Li,Wang Qian,Tianjiao Lu,Yaqian Yang,Guanling Song,Yunhua Hu
出处
期刊:Toxicology Mechanisms and Methods [Taylor & Francis]
卷期号:32 (1): 1-17 被引量:14
标识
DOI:10.1080/15376516.2021.1965277
摘要

Silica nanoparticles (SiNPs) have been widely used in nanotechnology, and more attention has been paid to their safety evaluation. However, there are still inconsistent conclusions about the genotoxicity of SiNPs. A systematic review was conducted to explore whether SiNPs have genotoxicity followed by a meta-analysis of in vivo and in vitro murine genotoxicity tests. A total of 26 eligible studies were identified in this meta-analysis through a detailed process of inclusion and exclusion, which included 9 in vivo studies, 15 in vitro studies, and 2 in both. The results of in vitro studies showed that SiNPs exposure significantly increased the indicators of the comet assay, such as tail DNA content (T DNA%), tail length (TL), and olive tail moment (OTM). Indicators of mutagenicity had not been affected in vitro studies, such as mutation frequency (MF) and micronucleus (MN) frequency. There was a significant increase in MN frequency, but there was no influence on T DNA% in vivo. Results of subgroup analysis indicated that size and treatment time of SiNPs were the associated factors in vitro genotoxicity. The size of SiNPs, <21 nm, induced more DNA damage than larger sized SiNPs. It could induce MN formation when the treatment time of SiNPs was <12 h, and even more DNA damage when the exposure time over 12 h. SiNPs can induce genotoxicity both in vivo and in vitro. Comet assay may be more sensitive to detect in vitro genotoxicity, and MN frequency may be more suitable to detect in vivo genotoxicity.
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