Abstract Shifting patterns of consumption in urban communities to consume pesticide-free and clean vegetables encourage the development of hydroponic cultivation in urban areas. In hydroponic lettuce cultivation, resource efficiency in the production stage is vital to be implemented so that the profits of hydroponic farmer increase. This study aims to provide recommendations for a more efficient hydroponic system to increase the growth of lettuce plants. The research method used in this study was a complete randomized design consisting of five treatments that were replicated five times. The treatment consists of five types of hydroponic installation systems, namely: A = Nutrient Film Technique System (NFT), B = Deep Film Technique System (DFT), C = EBB and FLOW Systems (EFS), D = Aeroponic Systems (AS), and E = Floating Raft System (RFS). The parameters observed to measure the effectiveness of each system in increasing the growth of lettuce plants are plant height, leaf number, fresh weight, and shoot-root ratio. The observational data were then analyzed using analysis of variance at 5% significance level and Duncan’s test at 5% level. The results showed that the NFT hydroponic system of lettuce plants was 6%-10% more efficient compared to the floating raft system and DFT system in increasing yields.