Risk factors for surgical site infection in head and neck cancer

医学 颈淋巴结清扫术 头颈部癌 糖尿病 逻辑回归 外科 口腔颌面外科 放射治疗 多元分析 风险因素 解剖(医学) 癌症 内科学 内分泌学
作者
Chengwen Gan,Yannan Wang,Yan Tang,Kai Wang,Bincan Sun,Mengxue Wang,Feiya Zhu
出处
期刊:Supportive Care in Cancer [Springer Science+Business Media]
卷期号:30 (3): 2735-2743 被引量:11
标识
DOI:10.1007/s00520-021-06687-8
摘要

Surgical site infection (SSI) frequently occurs in patients with head and neck cancer (HNC) after tumor resection and can lead to death in severe cases. Moreover, there is no definitive conclusion about the risk factors of SSI. Therefore, it is of great clinical significance to study the factors affecting the SSI.The HNC patients included in this study were all from the Department of Oral and Maxillofacial Surgery of the Second Xiangya Hospital of Central South University (CSU), and these patients received surgical treatment in the department from January 2018 to December 2019. The cross tabulation with chi-squared testing and multivariate regression analysis were applied to determine the risk factors of SSI. To identify the key risk factors of SSI, the caret package was used to construct three different machine learning models to investigate important features involving 26 SSI-related risk factors.Participants were 632 HNC patients who underwent surgery in our department from January 2018 to December 2019. During the postoperative period, 82 patients suffered from SSI, and surgical site infection rate (SSIR) was about 12.97%. Multivariate logistic regression analysis shows that diabetes mellitus, primary tumor site (floor of mouth), preoperative radiotherapy, flap failure, and neck dissection (bilateral) are risk factors for SSI of HNC. Machine learning indicated that diabetes mellitus, primary tumor site (floor of mouth), and flap failure were consistently ranked the top three in the 26 SSI-related risk factors.Diabetes mellitus, primary tumor site (floor of mouth), flap failure, preoperative radiotherapy, and neck dissection (bilateral) are risk factors for SSI of HNC.
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