已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

The Prognostic Value of Right Atrial Strain Imaging in Patients with Precapillary Pulmonary Hypertension

医学 内科学 心脏病学 肺楔压 心室 肺动脉 肺动脉高压 心力衰竭 四分位数 斑点追踪超声心动图 射血分数 置信区间
作者
Nina E. Hasselberg,Nobuyuki Kagiyama,Yuko Soyama,Masataka Sugahara,Akiko Goda,Keiko Ryo‐Koriyama,Omar Batel,Murali M. Chakinala,Marc A. Simon,John Gorcsan
出处
期刊:Journal of The American Society of Echocardiography [Elsevier]
卷期号:34 (8): 851-861.e1 被引量:42
标识
DOI:10.1016/j.echo.2021.03.007
摘要

Right ventricular (RV) failure in patients with pulmonary hypertension (PH) is associated with unfavorable clinical events and a poor prognosis. Elevation of right atrial (RA) pressure is established as a marker for RV failure. However, the additive prognostic value of RA mechanical function is unclear.The authors tested the hypothesis that RA function by strain echocardiography has prognostic usefulness by studying 165 consecutive patients with precapillary PH defined invasively: mean pulmonary artery pressure ≥ 25 mm Hg and pulmonary capillary wedge pressure < 15 mm Hg. Speckle-tracking strain analyses of the right atrium and right ventricle were performed, along with routine measures. Peak RA strain values from six segments using generic speckle-tracking software were averaged to RA peak longitudinal strain, representing RA global reservoir function. The primary end point was all-cause mortality during 5 years of follow-up. RA strain was similarly analyzed in a control group of 16 normal subjects for comparison.There were 151 patients with PH (mean age, 55 ± 16 years; 73% women; mean World Health Organization functional class, 2.6 ± 0.6), after 14 exclusions (three with atrial septal defects and 11 with left ventricular ejection fractions < 50%). RA strain measurement was feasible in 93% of patients and RV strain measurement in 88%. RA peak longitudinal strain was significantly reduced in patients with PH compared with control subjects, as expected (P < .001). During 5-year follow-up, 73 patients (48%) died. Patients with RA peak strain in the lowest quartile (<25%) had a significant risk for death (P = .006), even after correcting for confounding variables. RA strain was independently associated with survival in multivariate analysis (P = .039) and had additive prognostic value to RV strain (log-rank P = .01) in subgroup analysis.RA peak longitudinal strain had additive prognostic usefulness to other clinical measures, including RV strain, RA area, and RA pressure, in patients with PH. RA mechanical function by strain imaging has potential for clinical applications in patients with PH.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
威灵仙完成签到 ,获得积分10
5秒前
avaig完成签到 ,获得积分10
6秒前
7秒前
钱塘郎中完成签到,获得积分0
9秒前
三井库里发布了新的文献求助30
12秒前
杨tong完成签到 ,获得积分10
18秒前
Akim应助qyn1234566采纳,获得10
25秒前
Bububu关注了科研通微信公众号
25秒前
科研通AI2S应助科研通管家采纳,获得10
32秒前
科研通AI2S应助科研通管家采纳,获得10
32秒前
佳期发布了新的文献求助10
32秒前
jordanback应助科研通管家采纳,获得10
32秒前
香蕉觅云应助科研通管家采纳,获得10
32秒前
32秒前
科研通AI2S应助科研通管家采纳,获得10
32秒前
慕青应助科研通管家采纳,获得10
32秒前
核桃小丸子完成签到 ,获得积分10
34秒前
xyyyy完成签到 ,获得积分10
34秒前
35秒前
36秒前
苏格拉没有底完成签到 ,获得积分10
39秒前
流光完成签到 ,获得积分10
39秒前
39秒前
starlx0813发布了新的文献求助10
40秒前
热舞特完成签到,获得积分10
42秒前
干辣椒完成签到 ,获得积分10
52秒前
52秒前
快乐翠桃完成签到 ,获得积分10
54秒前
57秒前
一方通行发布了新的文献求助10
58秒前
小郭发布了新的文献求助10
1分钟前
中心湖小海棠完成签到,获得积分10
1分钟前
FERN0826完成签到 ,获得积分10
1分钟前
1分钟前
wangxiaobin完成签到,获得积分10
1分钟前
197819782009完成签到 ,获得积分0
1分钟前
克丽完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
浪浪完成签到 ,获得积分10
1分钟前
高分求助中
求助这个网站里的问题集 1000
Floxuridine; Third Edition 1000
Models of Teaching(The 10th Edition,第10版!)《教学模式》(第10版!) 800
La décision juridictionnelle 800
Rechtsphilosophie und Rechtstheorie 800
Nonlocal Integral Equation Continuum Models: Nonstandard Symmetric Interaction Neighborhoods and Finite Element Discretizations 500
Academic entitlement: Adapting the equity preference questionnaire for a university setting 500
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 免疫学 细胞生物学 电极
热门帖子
关注 科研通微信公众号,转发送积分 2871855
求助须知:如何正确求助?哪些是违规求助? 2479824
关于积分的说明 6720021
捐赠科研通 2166329
什么是DOI,文献DOI怎么找? 1151039
版权声明 585660
科研通“疑难数据库(出版商)”最低求助积分说明 565044