Rapid‐Fabricated and Recoverable Dual‐Network Hydrogel with Inherently Anti‐Bacterial Abilities for Potential Adhesive Dressings

Abstract To satisfy the ever‐accelerated demands for advanced engineering biomaterials with excellent physicochemical properties, injectable and recoverable dual‐network (DN) hydrogels based on poly( l ‐lysine)‐graft‐4‐hydroxyphenylacetic acid (PLL‐g‐HPA) and Aga are constructed by simply mixing PLL‐g‐HPA/HRP and PLL‐g‐HPA/H 2 O 2 in Aga through enzyme‐catalyzed cross‐linkage of PLL‐g‐HPA and temperature‐adjusted sol‐gel transition of Aga. The recoverable and injectable performances of hydrogels are attributed to the reversible sol‐gel transitional feature of Aga and enzymatically cross‐linked reaction of PLL‐g‐HPA. DN hydrogels have fast and adjusted gelation time, connective pore structure, superior formability, and good biocompatibility. The helically structural Aga network endows the hydrogels with good mechanical strength and superior stability in extreme condition. Schiff‐base effect between amino in skin tissues and carbonyl formed by the oxidation of phenol groups in hydrogel imparts the hydrogels to promising tissue attachment. Bursting pressure assay illustrates that the bursting pressure (34.5 ± 2.4 kPa) for 13.6% DN hydrogel is much higher than arterial blood pressure (16 kPa). The incorporated cationic PLL‐g‐HPA gives the hydrogels remarkable antibacterial ability, which effectively prevents the bacterial infection. In conclusion, the DN hydrogel with good cytocompatibility, inherently antibacterial ability, tissue adhesion, and excellent stability in extreme environment is probably able to become a promising candidate as potential wound dressings.