脱甲基酶
核糖核酸
病毒复制
细胞生物学
重编程
N6-甲基腺苷
RNA沉默
生物
信使核糖核酸
RNA干扰
化学
生物化学
病毒
病毒学
细胞
DNA
基因
甲基转移酶
甲基化
组蛋白
作者
Yang Liu,Yuling You,Zhike Lu,Yang Jiang,Panpan Li,Lun Liu,Henan Xu,Yamei Niu,Xuetao Cao
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2019-08-22
卷期号:365 (6458): 1171-1176
被引量:166
标识
DOI:10.1126/science.aax4468
摘要
RNA modification meets immune metabolism N 6 -methyladenosine (m 6 A) RNA modification regulates various cellular functions. Liu et al. found that host cells impair RNA m 6 A demethylase activity after viral infection, leading to increased m 6 A and reduced stability of α-ketoglutarate dehydrogenase (OGDH) mRNA. As a result, reduced OGDH decreases the generation of itaconate, thereby inhibiting viral replication. The authors explore the function of OGDH and itaconate in viral infection, provide insights into m 6 A RNA modification and metabolic reprogramming in modulating virus-host interaction, and suggest potential therapeutic targets for the control of viral infection. Science , this issue p. 1171
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