中枢神经系统
细胞毒性T细胞
CD8型
免疫学
生物
神经科学
抗原
免疫系统
生物化学
体外
作者
Stina L. Urban,Isaac J. Jensen,Qiang Shan,Lecia L. Pewe,Hai‐Hui Xue,Vladimir P. Badovinac,John T. Harty
标识
DOI:10.1038/s41590-020-0711-8
摘要
The central nervous system (CNS) is classically viewed as immune-privileged; however, recent advances highlight interactions between the peripheral immune system and CNS in controlling infections and tissue homeostasis. Tissue-resident memory (TRM) CD8+ T cells in the CNS are generated after brain infections, but it is unknown whether CNS infection is required to generate brain TRM cells. We show that peripheral infections generate antigen-specific CD8+ memory T cells in the brain that adopt a unique TRM signature. Upon depletion of circulating and perivascular memory T cells, this brain signature was enriched and the surveilling properties of brain TRM cells was revealed by intravital imaging. Notably, peripherally induced brain TRM cells showed evidence of rapid activation and enhanced cytokine production and mediated protection after brain infections. These data reveal that peripheral immunizations can generate brain TRM cells and will guide potential use of T cells as therapeutic strategies against CNS infections and neurological diseases.
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