Tadpole-like Unimolecular Nanomotor with Sub-100 nm Size Swims in a Tumor Microenvironment Model

Inspired by the natural motors capable of performing multiple tasks in complex living environments, synthetic nanomotors emerge as a potential vehicle for revolutionizing biomedical processes. Yet current motors suffer from decreased and even completely hindered motion in a complex physiological environment, shadowing the future of this booming field. To address this problem, a unimolecular nanomotor based on molecular bottlebrush (MBB) of sub-100 nm size is reported. This motor is constructed precisely via controlled radical polymerization and click chemistry and propelled with biocompatible catalase. Such a molecular nanomotor possesses tadpole-like asymmetry and is able to overcome Brownian motion, and demonstrates strong directional propulsion (linear and coiled cyclic trajectories) in a viscous tumor microenvironment gel model at an ultralow hydrogen peroxide level of 2 mM (0.006%). In addition, the molecular nanomotor exhibits superior stability in serum containing cell medium and good biocompatibility in blood. Such molecular bottlebrush based nanomotors may represent a unique platform for overcoming the tissue penetration barrier.