认知
睡眠(系统调用)
混淆
人口
横断面研究
纵向研究
医学
活动记录
睡眠剥夺对认知功能的影响
老年学
听力学
昼夜节律
精神科
内科学
环境卫生
病理
操作系统
计算机科学
作者
Mingyue Hu,Xinhui Shu,Hui Feng,Lily Dongxia Xiao
标识
DOI:10.1016/j.jad.2021.02.013
摘要
Sleep plays a key role in preserving cognitive function. However, the optimal strategies of sleep for cognition and the underlying mechanism are not well-established. A cross-sectional study was performed using the China Health and Retirement Longitudinal Study (CHARLS), 2011-2012 survey. Self-reported nighttime sleep and afternoon napping data were collected. Fasting blood collected was analyzed for the high-sensitivity C-reactive protein (CRP) and white blood cell. Both nighttime sleep and afternoon napping were significantly associated with cognition after adjusting for confounders (p < 0.05). Precisely, participants with nighttime sleep of 6.1-7h had the highest cognition scores (p < 0.05). Participants with less than 30 min afternoon napping had the highest cognition scores (p < 0.05). The synergistic effect of nighttime sleep and afternoon napping was not significant (p > 0.05). Nighttime sleep and afternoon napping were significantly related to the white blood cell, but not the high-sensitivity CRP. The white blood cell mediated the association between sleep and cognition (p < 0.05). Nighttime sleep of six to seven hours and afternoon napping of less than 30 minutes are associated with optimal cognitive function in middle-aged and older people, respectively. Sleep influences cognition partly via the inflammatory profile.
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