甲型流感病毒
细胞凋亡
活性氧
病毒
体内
DNA断裂
蛋白激酶B
硒
化学
碎片(计算)
信号转导
生物
细胞生物学
病毒学
程序性细胞死亡
生物化学
有机化学
生物技术
生态学
作者
Changbing Wang,Haiyang Chen,Danyang Chen,Mingqi Zhao,Zhengfang Lin,Min Guo,Tiantian Xu,Yi Chen,Liang Hua,Tao Lin,Ying Tang,Bing Zhu,Yinghua Li
出处
期刊:ACS omega
[American Chemical Society]
日期:2020-11-16
卷期号:5 (47): 30633-30642
被引量:31
标识
DOI:10.1021/acsomega.0c04624
摘要
β-Thujaplicin possess a variety of biological activities. The use of modified biological nanoparticles (NPs) to develop novel anti-influenza drugs has increased in recent years. Selenium nanoparticles (SeNPs) with antiviral activity have attracted increasing attention for biomedical intervention. Functionalized SeNPs by β-thujaplicin (Se@TP) surface modified with superior antiviral activity were synthesized in this study. Compared to a virus group (43%), when treated with Se@TP (88%), the cell survival rate of MDCK cells was 45% higher. Se@TP could inhibit H1N1 from infecting Madin-Darby canine kidney (MDCK) cells and block chromatin condensation and DNA fragmentation. Se@TP obviously prevented MDCK cells from generating reactive oxygen species. Furthermore, Se@TP prevents lung injury in H1N1-infected mice through eosin staining and hematoxylin in vivo. Mechanistic investigation revealed that Se@TP inhibited H1N1 influenza virus from infecting MDCK cells through induction of apoptosis via suppressing AKT and p53 signaling pathways through immunohistochemical assay. Our results suggest that β-thujaplicin-modified SeNPs as carriers are an efficient way to achieve an antiviral pharmaceutical candidate for H1N1 influenza.
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