化学
催化作用
芳基
镍
键裂
催化循环
劈理(地质)
药物化学
基质(水族馆)
组合化学
立体化学
有机化学
烷基
海洋学
地质学
工程类
断裂(地质)
岩土工程
作者
Zhen Wang,Yuanyuan Hu,Hongwei Jin,Yunkui Liu,Bingwei Zhou
标识
DOI:10.1021/acs.joc.0c02209
摘要
Herein, we first present a nickel-catalyzed arylation and alkenylation of tert-cyclobutanols with aryl/alkenyl triflates via a C–C bond cleavage. An array of γ-substituted ketones was obtained in moderate-to-good yields, thus featuring earth-abundant nickel catalysis, broad substrate scope, and simple reaction conditions. Preliminary mechanistic experiments indicated that β-carbon elimination pathways might be involved in the catalytic cycle.
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