Common brain disorders are associated with heritable patterns of apparent aging of the brain

脑老化大脑结构与功能脑功能神经科学多效性大脑大小神经影像学大脑发育心理学衰老的大脑生物医学认知遗传学表型磁共振成像基因放射科

作者

Tobias Kaufmann,Dennis van der Meer,Nhat Trung Doan,Emanuel Schwarz,Martina J. Lund,Ingrid Agartz,Dag Alnæs,Deanna M. Barch,Ramona Baur‐Streubel,Alessandro Bertolino,Francesco Bettella,Mona K. Beyer,Erlend Bøen,Stefan Borgwardt,Christine L. Brandt,Jan K. Buitelaar,Elisabeth Gulowsen Celius,Simon Červenka,Annette Conzelmann,Aldo Córdova‐Palomera,Anders M. Dale,Dominique J.‐F. de Quervain,Pasquale Di Carlo,Srdjan Djurovic,Erlend S. Dørum,Sarah Eisenacher,Torbjørn Elvsåshagen,Thomas Espeseth,Helena Fatouros‐Bergman,Lena Flyckt,Barbara Franke,Oleksandr Frei,Beathe Haatveit,Asta K. Håberg,Hanne F. Harbo,Catharina A. Hartman,Dirk J. Heslenfeld,Pieter J. Hoekstra,Einar A. Høgestøl,Terry L. Jernigan,Rune Jonassen,Erik G. Jönsson,Peter Kirsch,Iwona Kłoszewska,Knut K. Kolskår,Nils Inge Landrø,Stéphanie Le Hellard,Klaus‐Peter Lesch,Simon Lovestone,Arvid Lundervold,Astri J. Lundervold,Luigi A. Maglanoc,Ulrik Fredrik Malt,Patrizia Mecocci,Ingrid Melle,Andreas Meyer‐Lindenberg,Torgeir Moberget,Linn B. Norbom,Jan Egil Nordvik,Lars Nyberg,Jaap Oosterlaan,Marco Papalino,Andreas Papassotiropoulos,Paul Pauli,Giulio Pergola,Karin Persson,Geneviève Richard,Jaroslav Rokicki,Anne‐Marthe Sanders,Geir Selbæk,Alexey Shadrin,Olav B. Smeland,Hilkka Soininen,Piotr Sowa,Vidar M. Steen,Magda Tsolaki,Kristine M. Ulrichsen,Bruno Vellas,Lei Wang,Eric Westman,Georg Ziegler,Mathias Zink,Ole A. Andreassen,Lars T. Westlye

出处

期刊：Nature Neuroscience [Nature Portfolio]
日期：2019-09-24 卷期号：22 (10): 1617-1623 被引量：457

链接

nih.gov biorxiv.org nih.govdoi.org

标识

DOI：10.1038/s41593-019-0471-7

摘要

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

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Common brain disorders are associated with heritable patterns of apparent aging of the brain

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