Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam

In this paper, we identified a cocrystal conglomerate of mandelic acid using a drug compound as a coformer. We then developed a chiral resolution process based on preferential cocrystallization. Several versions of such a process were explored and optimized, leading to a successful resolution of mandelic acid, evidencing the efficiency of our system. Excellent enantiopurity (98–99%) was obtained with a process that can run for multiple cycles.