嵌合抗原受体
神经毒性
癌症研究
神经母细胞瘤
毒性
抗原
医学
受体
生物
药理学
免疫学
T细胞
内科学
细胞培养
免疫系统
遗传学
作者
Karin Straathof,Barry Flutter,Rebecca Wallace,Neha Jain,Thalia Loka,Sarita Depani,Gary Wright,Simon Thomas,Gordon Weng-Kit Cheung,Talia Gileadi,Sian Stafford,Evangelia Kokalaki,Jack Barton,Clare Marriott,Dyanne Rampling,Olumide Ogunbiyi,Ayse U. Akarca,Teresa Marafioti,Sarah Inglott,Kimberly Gilmour
标识
DOI:10.1126/scitranslmed.abd6169
摘要
Patients with neuroblastoma infused with GD2-directed CAR-T cells experienced immune activation and transient tumor regressions without neurotoxicity.
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