溶血磷脂酸
卵巢癌
生物标志物
阶段(地层学)
癌症
临床意义
肿瘤科
内科学
癌症研究
化学
医学
生物
生物化学
古生物学
受体
作者
Nian-Sheng Li,Li Chen,Zuoxiu Xiao,Yuqi Yang,Kelong Ai
出处
期刊:Chinese Journal of Analytical Chemistry
[China Science Publishing & Media Ltd.]
日期:2020-12-01
卷期号:48 (12): 1597-1606
被引量:3
标识
DOI:10.1016/s1872-2040(20)60062-7
摘要
Ovarian cancer is a serious threat to women's health, and its mortality rate is the highest in gynecological cancer. At present, there is a lack of effective and convenient early diagnosis techniques for ovarian cancer. Most of the patients with ovarian cancer are found in the middle and late stage, thus missing the best time for treatment. Therefore, the rapid, sensitive, economic and accurate detection of early ovarian cancer is of great significance. In recent years, lysophosphatidic acid (LPA) has been found to increase in serum in the early stage of ovarian cancer, but less in other diseases. Therefore, LPA is a promising and highly specific marker of ovarian cancer. To detect LPA, many detection techniques have been developed, and great progress has been made in this field. This paper summarizes the detection methods of LPA, and focuses on the important progress in this field in recent years. Finally, the challenges and prospects of LPA marker detection in real clinical application are also prospected.
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