吡唑
利莫那班
化学
戒指(化学)
组合化学
药理学
立体化学
兴奋剂
受体
生物化学
有机化学
大麻素受体
生物
作者
Fatima Ezzahra Bennani,Latifa Doudach,Yahia Cherrah,Youssef Ramli,Khalid Karrouchi,M’hammed Ansar,My El Abbés Faouzi
标识
DOI:10.1016/j.bioorg.2019.103470
摘要
Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C3H3N2H.The presence of this nucleus in pharmacological agents of various therapeutic categories gifts a broad spectrum of biological activities and pharmaceuticals that contain pyrazole like celecoxib (anti-inflammatory), CDPPB (antipsychotic), Rimonabant (anti-obesity), Difenamizole, (Analgesic), Betazole (H2 receptor agonist), Fezolamide (Antidepressant), etc… The pharmacological potential of the pyrazole fraction is proved in many publication where they synthesized and evaluated pyrazoles against several biological agents. The aim of this article review is to survey recent works linking pyrazole structures to anticancer activities corresponding to 9 different type of cancer.
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