半胱氨酸
化学
表位
半胱氨酸蛋白酶
氨基酸
二硫键
肽
蛋白质工程
残留物(化学)
生物化学
功能(生物学)
抗体
生物
酶
细胞生物学
免疫学
作者
Rafael González‐Castro,Miguel A. Gómez‐Lim,Fabien Plisson
出处
期刊:ChemBioChem
[Wiley]
日期:2020-11-17
卷期号:22 (6): 961-973
被引量:23
标识
DOI:10.1002/cbic.202000634
摘要
Abstract Cysteine‐rich peptides (CRPs) are small proteins of less than 100 amino acids in length characterized by the presence of disulfide bridges and common end‐to‐end macrocyclization. These properties confer hyperstability against high temperatures, salt concentration, serum presence, and protease degradation to CRPs. Moreover, their intercysteine domains (loops) are susceptible to residue hypervariability. CRPs have been successfully applied as stable scaffolds for molecular grafting, a protein engineering process in which cysteine‐rich structures provide higher thermodynamic and metabolic stability to an epitope and acquire new biological function(s). This review describes the successes and limitations of seven cysteine‐rich scaffolds, their bioactive epitopes, and the resulting grafted peptides.
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