幽门螺杆菌
癌症
生物
癌变
恶性肿瘤
癌症研究
遗传学
作者
Narges Dastmalchi,Seyed Mahdi Banan Khojasteh,Mirsaed Miri Nargesi,Reza Safaralizadeh
出处
期刊:Pathogens and Disease
[Oxford University Press]
日期:2019-12-01
卷期号:77 (9)
被引量:14
标识
DOI:10.1093/femspd/ftaa004
摘要
Helicobacter pylori infection performs a key role in gastric tumorigenesis. Long non-coding RNAs (lncRNAs) have demonstrated a great potential to be regarded as effective malignancy biomarkers for various gastrointestinal diseases including gastric cancer (GC). The present review highlights the relationship between lncRNAs and H. pylori in GC. Several studies have examined not only the involvement of lncRNAs in H. pylori-associated GC progression but also their molecular mechanisms of action. Among the pertinent studies, some have addressed the effects of H. pylori infection on modulatory networks of lncRNAs, while others have evaluated the effects of changes in the expression level of lncRNAs in H. pylori-associated gastric diseases, especially GC. The relationship between lncRNAs and H. pylori was found to be modulated by various molecular pathways.
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