CIRCADIAN RHYTHM DISRUPTION INDUCED BY ALTERNATING LIGHT-DARK CYCLE AGGRAVATES CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION THROUGH SCN-PVN-SCG-HEART SYMPATHETIC PATHWAY

Circadian rhythms have a considerable impact on the daily physiology of organisms, and their disruption causes pathology. Studies have revealed that circadian rhythm disruption induced by alternating light-dark cycle could impair cardiac remodeling, however, the underlying mechanisms remain unknown