药品
药物开发
芯片上器官
心脏毒性
医学
炸薯条
药理学
生物医学工程
纳米技术
计算机科学
材料科学
内科学
化疗
微流控
电信
作者
Li Ren,Xingwu Zhou,Rohollah Nasiri,Jun Fang,Xing Jiang,Canran Wang,Moyuan Qu,Haonan Ling,Yihang Chen,Yumeng Xue,Martin C. Hartel,Peyton Tebon,Shiming Zhang,Han‐Jun Kim,Xichen Yuan,Amir Shamloo,Mehmet R. Dokmeci,Song Li,Ali Khademhosseini,Samad Ahadian,Wujin Sun
标识
DOI:10.1002/smtd.202000438
摘要
Animal models and traditional cell cultures are essential tools for drug development. However, these platforms can show striking discrepancies in efficacy and side effects when compared to human trials. These differences can lengthen the drug development process and even lead to drug withdrawal from the market. The establishment of preclinical drug screening platforms that have higher relevancy to physiological conditions is desirable to facilitate drug development. Here, a heart-on-a-chip platform, incorporating microgrooves and electrical pulse stimulations to recapitulate the well-aligned structure and synchronous beating of cardiomyocytes (CMs) for drug screening, is reported. Each chip is made with facile lithographic and laser-cutting processes that can be easily scaled up to high-throughput format. The maturation and phenotypic changes of CMs cultured on the heart-on-a-chip is validated and it can be treated with various drugs to evaluate cardiotoxicity and cardioprotective efficacy. The heart-on-a-chip can provide a high-throughput drug screening platform in preclinical drug development.
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