作者
Hui Jin,Tao Huang,Ruifang Wu,Ming Zhao,Haijing Wu,Hai Long,Heng Yin,Jieyue Liao,Shuangyan Luo,Yu Liu,Qing Zhang,Peng Zhang,Yixin Tan,Shuaihantian Luo,Xin Huang,Yaxiong Deng,Wei Liao,Liu Duan,Jianbo Chen,Yin Zhou,Jinghua Yin,Hong Qiu,Jin Yuan,Zijun Wang,Mengying Li,Xiaoqi Wu,Lina Chen,Liangmin Cai,Cancan Huang,Qianwen Li,Boyu Tang,Bihui Yu,Xin Li,Xiaofei Gao,Yixi Hu,Xiaolei Ren,Haofan Xue,Zhangming Wei,Jinwei Chen,Fen Li,Guanghui Ling,Hui Luo,Hongjun Zhao,Sen Yang,Yong Cui,Youkun Lin,Xu Yao,Lingyun Sun,Qing Guo,Hong Fang,Kang Zeng,Danqi Deng,Jianzhong Zhang,Yuzhen Li,Xiong-ming Pu,Xiaoqin Liao,Xiqiang Dang,Danlin Huang,Yumei Liang,Qing Sun,Huixu Xie,Li Zeng,Cibo Huang,Qingchun Diao,Juan Tao,Jianbin Yu,Zhenlu Li,Hanshi Xu,Hui Li,Wei Lai,Xiguang Liu,Jingjing Wu,Tienan Li,Tiechi Lei,Qiuning Sun,Yanjia Li,Guoqiang Zhang,Xin Huang,Qianjin Lu
摘要
Although the original purpose of the systemic lupus erythematosus (SLE) classification criteria was to distinguish SLE from other mimic diseases, and to facilitate sample selection in scientific research, they have become widely used as diagnostic criteria in clinical situations. It is not known yet if regarding classification criteria as diagnostic criteria, what problems might be encountered? This is the first study comparing the three sets of classification criteria for SLE, the 1997 American College of Rheumatology (ACR’97), 2012 Systemic Lupus International Collaborating Clinics (SLICC’12) and 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR’19), for their ability to distinguish patients with SLE from patients with pure mucocutaneous manifestations (isolated cutaneous lupus erythematosus without internal disease, i-CLE) in the lupus disease spectrum. 1,865 patients with SLE and 232 patients with i-CLE were recruited from a multicenter study. We found that, due to low specificity, none of the three criteria are adept at distinguishing patients with SLE from patients with i-CLE. SLICC’12 performed best among the original three criteria, but if a positive ANA was removed as an entry criterion, EULAR/ACR’19 would performed better. A review of previous studies that compared the three sets of criteria was presented in this work.