Lipidomic alteration of plasma in cured COVID-19 patients using ultra high-performance liquid chromatography with high-resolution mass spectrometry

血脂异常 2019年冠状病毒病(COVID-19) 脂类学 大流行 鉴别诊断 医学 内科学 液相色谱-质谱法 单变量分析 多元分析 化学 疾病 质谱法 生物化学 病理 色谱法 传染病(医学专业)
作者
Yunpeng Bai,Wendong Huang,Yaocai Li,Changchun Lai,Sumei Huang,Guangwen Wang,Yuemei He,Linhui Hu,Chunbo Chen
出处
期刊:Bioscience Reports [Portland Press]
卷期号:41 (3) 被引量:25
标识
DOI:10.1042/bsr20204305
摘要

Abstract Background: The pandemic of novel coronavirus disease 2019 (COVID-19) has become a serious public health crisis worldwide. The symptoms of COVID-19 vary from mild to severe among different age groups, but the physiological changes related to COVID-19 are barely understood. Methods: In the present study, a high-resolution mass spectrometry (HRMS)-based lipidomic strategy was used to characterize the endogenous plasma lipids for cured COVID-19 patients with different ages and symptoms. These patients were further divided into two groups: those with severe symptoms or who were elderly and relatively young patients with mild symptoms. In addition, automated lipidomic identification and alignment was conducted by LipidSearch software. Multivariate and univariate analyses were used for differential comparison. Results: Nearly 500 lipid compounds were identified in each cured COVID-19 group through LipidSearch software. At the level of lipid subclasses, patients with severe symptoms or elderly patients displayed dramatic changes in plasma lipidomic alterations, such as increased triglycerides and decreased cholesteryl esters (ChE). Some of these differential lipids might also have essential biological functions. Furthermore, the differential analysis of plasma lipids among groups was performed to provide potential prognostic indicators, and the change in signaling pathways. Conclusions: Dyslipidemia was observed in cured COVID-19 patients due to the viral infection and medical treatment, and the discharged patients should continue to undergo consolidation therapy. This work provides valuable knowledge about plasma lipid markers and potential therapeutic targets of COVID-19 and essential resources for further research on the pathogenesis of COVID-19.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
称心凡霜完成签到,获得积分10
2秒前
2秒前
krkr发布了新的文献求助10
4秒前
1hforrest应助顺心孤云采纳,获得10
4秒前
于夜柳发布了新的文献求助10
5秒前
7秒前
黄桃酥完成签到 ,获得积分10
8秒前
爽_完成签到,获得积分10
8秒前
土豪的鸿煊完成签到,获得积分10
11秒前
如是之人发布了新的文献求助10
11秒前
Orange应助lvben采纳,获得10
13秒前
爆米花应助搬运工采纳,获得30
14秒前
15秒前
尘烟完成签到 ,获得积分10
17秒前
斯文败类应助小平采纳,获得10
19秒前
sam发布了新的文献求助10
19秒前
江南最后的深情完成签到,获得积分10
22秒前
烟花应助mk采纳,获得10
23秒前
英俊的铭应助李李采纳,获得10
25秒前
木子完成签到,获得积分10
27秒前
29秒前
xl完成签到,获得积分10
30秒前
30秒前
33秒前
mk发布了新的文献求助10
34秒前
34秒前
35秒前
三金脚脚完成签到 ,获得积分10
37秒前
飞龙完成签到,获得积分10
38秒前
39秒前
40秒前
木子发布了新的文献求助10
40秒前
英俊的铭应助lmslms采纳,获得10
41秒前
小平发布了新的文献求助10
41秒前
重要忆秋完成签到,获得积分10
41秒前
43秒前
华仔应助呆呆瓜采纳,获得10
43秒前
魏雪梅shirley完成签到,获得积分10
44秒前
yanghaobo完成签到,获得积分10
44秒前
Hello应助乐橙采纳,获得10
44秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3161007
求助须知:如何正确求助?哪些是违规求助? 2812311
关于积分的说明 7895133
捐赠科研通 2471181
什么是DOI,文献DOI怎么找? 1315908
科研通“疑难数据库(出版商)”最低求助积分说明 631071
版权声明 602086