Efficient Synthesis of 4H-Pyran and Spiro-Oxindole Derivatives Based on Al2O3/V2O5 Nanocomposite as Catalyst

A simple and eco-friendly catalytic alternative has been proposed for one-pot three-component synthesis of 4H-pyrane and spiro-oxindole derivatives, as two important classes of potentially bioactive compounds, in the presence of a catalytic amount of Al2O3/V2O5 nanocomposite. Good to excellent yields and short reaction times were obtained for both series of Al2O3/V2O5-catalyzed reactions. In addition, the Al2O3/V2O5 nanocatalyst can be reused without appreciable loss of activity. The obtained results suggest prospects of using Al2O3/V2O5 nanocomposite as potent heterogeneous catalyst in other syntheses.