凝集素
认知
认知功能衰退
炎症
疾病
神经可塑性
神经科学
补体系统
医学
内科学
心理学
免疫学
生物
神经炎症
细胞凋亡
痴呆
免疫系统
生物化学
作者
Zurine De Miguel,Nathalie Khoury,Michael J. Betley,Benoit Lehallier,Drew Willoughby,Niclas Olsson,Andrew C. Yang,Oliver Hahn,Nannan Lu,Ryan T. Vest,Liana Bonanno,Lakshmi Yerra,Lichao Zhang,Nay L. Saw,J. Kaci Fairchild,Davis Lee,Hui Zhang,Patrick L. McAlpine,Kévin Contrepois,Mehrdad Shamloo,Joshua E. Elias,Thomas A. Rando,Tony Wyss‐Coray
出处
期刊:Nature
[Springer Nature]
日期:2021-12-08
卷期号:600 (7889): 494-499
被引量:218
标识
DOI:10.1038/s41586-021-04183-x
摘要
Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration1. The cognitive benefits of physical exercise are tied to an increased plasticity and reduced inflammation within the hippocampus2–4, yet little is known about the factors and mechanisms that mediate these effects. Here we show that ‘runner plasma’, collected from voluntarily running mice and infused into sedentary mice, reduces baseline neuroinflammatory gene expression and experimentally induced brain inflammation. Plasma proteomic analysis revealed a concerted increase in complement cascade inhibitors including clusterin (CLU). Intravenously injected CLU binds to brain endothelial cells and reduces neuroinflammatory gene expression in a mouse model of acute brain inflammation and a mouse model of Alzheimer’s disease. Patients with cognitive impairment who participated in structured exercise for 6 months had higher plasma levels of CLU. These findings demonstrate the existence of anti-inflammatory exercise factors that are transferrable, target the cerebrovasculature and benefit the brain, and are present in humans who engage in exercise. Plasma from voluntarily running mice reduces baseline expression of neuroinflammatory genes and experimentally induced brain inflammation when infused into sedentary mice.
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