药物输送
生物复合材料
哮喘
肺
医学
肺纤维化
药品
靶向给药
慢性阻塞性肺病
材料科学
纳米技术
免疫学
药理学
内科学
复合数
复合材料
作者
Dhrubojyoti Mukherjee,Shvetank Bhatt
出处
期刊:Nanomedicine
日期:2022-04-28
卷期号:17 (12): 845-863
被引量:2
标识
DOI:10.2217/nnm-2021-0425
摘要
Diseases related to the lungs are among the most prevalent medical problems threatening human life. The treatment options and therapeutics available for these diseases are hindered by inadequate drug concentrations at pathological sites, a dearth of cell-specific targeting and different biological barriers in the alveoli or conducting airways. Nanostructured delivery systems for lung drug delivery have been significant in addressing these issues. The strategies used include surface engineering by altering the material structure or incorporation of specific ligands to reach prespecified targets. The unique characteristics of nanoparticles, such as controlled size and distribution, surface functional groups and therapeutic release triggering capabilities, are tailored to specific requirements to overcome the major therapeutic barriers in pulmonary diseases. In the present review, the authors intend to deliver significant up-to-date research in nanostructured therapies in inflammatory lung diseases with an emphasis on biocomposite-based nanoparticles.
科研通智能强力驱动
Strongly Powered by AbleSci AI