生物
黄病毒
寄主(生物学)
基孔肯雅
登革热
病毒学
微生物学
黄热病
伊蚊
载体(分子生物学)
病毒
生态学
重组DNA
生物化学
基因
作者
Hong Zhang,Yibin Zhu,Ziwen Liu,Yongmei Peng,Wenyu Peng,Liangqin Tong,Jinglin Wang,Qiyong Liu,Penghua Wang,Gong Cheng
出处
期刊:Cell
[Elsevier]
日期:2022-07-01
卷期号:185 (14): 2510-2522.e16
被引量:48
标识
DOI:10.1016/j.cell.2022.05.016
摘要
The host-seeking activity of hematophagous arthropods is essential for arboviral transmission. Here, we demonstrate that mosquito-transmitted flaviviruses can manipulate host skin microbiota to produce a scent that attracts mosquitoes. We observed that Aedes mosquitoes preferred to seek and feed on mice infected by dengue and Zika viruses. Acetophenone, a volatile compound that is predominantly produced by the skin microbiota, was enriched in the volatiles from the infected hosts to potently stimulate mosquito olfaction for attractiveness. Of note, acetophenone emission was higher in dengue patients than in healthy people. Mechanistically, flaviviruses infection suppressed the expression of RELMα, an essential antimicrobial protein on host skin, thereby leading to the expansion of acetophenone-producing commensal bacteria and, consequently, a high acetophenone level. Given that RELMα can be specifically induced by a vitamin A derivative, the dietary administration of isotretinoin to flavivirus-infected animals interrupted flavivirus life cycle by reducing mosquito host-seeking activity, thus providing a strategy of arboviral control.
科研通智能强力驱动
Strongly Powered by AbleSci AI