炎症
小胶质细胞
结肠炎
多酚
TLR4型
化学
肠道菌群
促炎细胞因子
药理学
信号转导
食品科学
生物化学
免疫学
生物
抗氧化剂
作者
Sen Li,Yu Chen,Yu Zhang,Huiying Lv,Lei Luo,Shuo Wang,Xiao Guan
标识
DOI:10.1021/acs.jafc.2c02079
摘要
Coffee cherry husks, the main byproduct of coffee production, contain an abundance of polyphenols. In this study, dextran sodium sulfate (DSS)-induced colitis mice were used to study the protective effects of polyphenolic extracts of coffee cherry husks (CCHP) on inflammation. The results indicated that CCHP administration alleviated the histological changes of DSS-induced colitis in mice and downregulated the mRNA level of TNF-α, IL-1β, IL-6 and Cox-2. Interestingly, CCHP inhibited the activation of microglia and suppressed neural inflammation in the brain. The TLR4/Myd88/NF-κB signaling pathway was examined and found to be inhibited by CCHP. Furthermore, a determination of the gut microbiota showed that an alteration of microbiota induced by DSS was restored by CCHP, including the decrease of the relative abundance of Proteobacteria and the increase of Bacteroidota. In conclusion, our results revealed the great potential of CCHP to alleviate brain inflammation in colitis mice by inhibiting the NF-κB signaling pathway and regulating gut microbiota.
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