痴呆
神经病理学
糖尿病
观察研究
认知功能衰退
2型糖尿病
病态的
认知
医学
代谢综合征
萎缩
内科学
风险因素
生物信息学
精神科
内分泌学
疾病
生物
作者
Mariam Kirvalidze,Alexander Hodkinson,Dawid Storman,Timothy J. Fairchild,Małgorzata M Bała,Giorgi Beridze,Ana Zuriaga,Nicoleta I. Brudasca,Stefano Brini
标识
DOI:10.1016/j.neubiorev.2022.104551
摘要
Excessive blood glucose promotes neuropathological cognitive decline in individuals with type 2 diabetes mellitus and the metabolic syndrome, but no systematic synthesis of the evidence for the same association exists in individuals without these conditions. To systematically review studies exploring the role of glucose on cognition, dementia risk, and related biomarkers in adults without diabetes or metabolic syndrome. We searched databases from inception until July 2021 and manually searched the reference lists of included studies. Risk of bias was assessed using the Joanna Briggs Institute tool. We found 46 observational studies including approximately 98,216 participants. Substantial heterogeneity in study results precluded drawing definitive conclusion whether blood glucose levels are associated with cognition or dementia risk. Higher blood glucose, however, was associated with greater amyloid burden, brain atrophy, and reduced cortical thickness. High glucose concentrations in blood may exacerbate dementia-related neuropathology but whether this translates into pathological cognitive decline or elevate dementia risk later in life remains unclear.
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