自身免疫
医学
类风湿性关节炎
免疫学
免疫系统
炎症
自身免疫性疾病
关节炎
背景(考古学)
获得性免疫系统
免疫病理学
免疫失调
生物
抗体
古生物学
作者
Florencia Rosetti,Iris K. Madera‐Salcedo,Noé Rodríguez‐Rodríguez,José C. Crispín
标识
DOI:10.1038/s41584-021-00741-9
摘要
Adaptive immune responses rely on the proliferation of T lymphocytes able to recognize and eliminate pathogens. The magnitude and duration of the expansion of activated T cell clones are finely regulated to minimize immunopathology and avoid autoimmunity. In patients with rheumatic autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, activated lymphocytes survive and exert effector functions for prolonged periods, defying the mechanisms that normally curb their capacities during acute and chronic infections. Here, we review the molecular mechanisms that limit the duration of immune responses in health and discuss the factors that alter such regulation in the setting of systemic lupus erythematosus and rheumatoid arthritis. We highlight defects that could contribute to the development and progression of autoimmune disease and describe how chronic inflammation can alter the regulation of activated lymphocyte survival, promoting its perpetuation. These concepts might contribute to the understanding of the mechanisms that underlie the chronicity of inflammation in the context of autoimmunity.
科研通智能强力驱动
Strongly Powered by AbleSci AI