Polymer Supported Proline-Based Organocatalysts in Asymmetric Aldol Reactions: A Review

Abstract: The use of proline-based organocatalysts has acquired significant attention in organic synthesis, especially in enantioselective synthesis. Proline and its derivatives are proven to be quite effective chiral organocatalysts for a variety of transformations, including the aldol reaction, which is considered as one of the important C-C bond forming reactions in organic synthesis. The use of chiral organocatalysts has several advantages over its metal-mediated analogues. Subsequently, a large number of highly efficient proline-based organocatalysts, including polymer-supported chiral analogues, have been identified for aldol reaction. The use of polymer-supported organocatalysts exhibited remarkable stability under the reaction conditions and offered the best results, particularly in terms of its recyclability and reusability. These potential benefits along with their economic and green chemistry advantages have led to the search for many polymer-supported proline catalysts. In this review, recent developments in exploring various polymer immobilized proline- based chiral organocatalysts for asymmetric aldol reactions are described.