微波消融
癌症研究
医学
血管生成
化学
内科学
烧蚀
作者
Qidi Hou,Kun Zhang,Sitong Chen,Jie Chen,Yan Zhang,Ningqiang Gong,Weisheng Guo,Chao Fang,Luo Wang,Jian Jiang,Jianping Dou,Xing‐Jie Liang,Jie Yu,Ping Liang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-03-30
卷期号:16 (4): 5704-5718
被引量:32
标识
DOI:10.1021/acsnano.1c10714
摘要
Ionic liquid (IL)-loaded or metal ions-enriched nanoparticles have been witnessed to assist microwave ablation (MWA) and heighten heat utilization for tumor treatment, which, however, inevitably brings about cell dys-homeostasis and severely endangers normal cells or tissues. In this report, a nonionic MWA sensitizer that encapsulates ethyl formate (EF) and doxorubicin (DOX) in liposomes (EF-DOX-Lips) was constructed to reinforce MWA and combined therapy against incomplete MWA-induced tumor recurrence. EF in EF-DOX-Lips as the nonionic liquid can perform like IL to accelerate energy transformation from electromagnetic energy to heat for strengthening MWA. More significantly, EF metabolite, that is, ethanol, also enables chemical ablation, which further enhances MWA. As well, the EF gasification-enhanced lipid rupture and cavitation can promote DOX delivery into a liver tumor for magnifying MWA & chemotherapy combined therapy. By virtue of these contributions, this nonionic MWA nanosensitizer exerts robust antitumor effects to inhibit tumor proliferation and angiogenesis for repressing tumor growth and recurrence or metastasis via downregulating the Epha2 gene and unconventional PI3K/Akt & MAPK signal pathways that the incomplete MWA activated, which provides an avenue to elevate an MWA-based antitumor outcome.
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