普罗布考
氧化应激
活性氧
化学
体内
病态的
药理学
炎症
胆固醇
生物化学
医学
内科学
生物
生物技术
作者
Xiaoyu Liang,Huiyang Li,Xuanling Li,Xinxin Tian,Aiai Zhang,Qiong Luo,Jianwei Duan,Youlu Chen,Liyun Pang,Chen Li,Xing‐Jie Liang,Yong Zeng,Jing Yang
标识
DOI:10.1016/j.apsb.2022.04.002
摘要
In atherosclerosis, chronic inflammatory processes in local diseased areas may lead to the accumulation of reactive oxygen species (ROS). In this study, we devised a highly sensitive H2O2-scavenging nano-bionic system loaded with probucol (RPP-PU), to treat atherosclerosis more effectively. The RPP material had high sensitivity to H2O2, and the response sensitivity could be reduced from 40 to 10 μmol/L which was close to the lowest concentration of H2O2 levels of the pathological environment. RPP-PU delayed the release and prolonged the duration of PU in vivo. In Apolipoprotein E deficient (ApoE‒/‒) mice, RPP-PU effectively eliminated pathological ROS, reduced the level of lipids and related metabolic enzymes, and significantly decreased the area of vascular plaques and fibers. Our study demonstrated that the H2O2-scavenging nano-bionic system could scavenge the abundant ROS in the atherosclerosis lesion, thereby reducing the oxidative stress for treating atherosclerosis and thus achieve the therapeutic goals with atherosclerosis more desirably.
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