谱系(遗传)
生物
免疫学
癌症
树突状细胞
获得性免疫系统
抗原
基因
遗传学
作者
Egle Kvedaraite,Florent Ginhoux
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2022-04-01
卷期号:7 (70)
被引量:145
标识
DOI:10.1126/sciimmunol.abm9409
摘要
Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating innate and adaptive immunity during infections, autoimmune diseases, and malignancies. Since the discovery of DCs almost 50 years ago, our understanding of their biology in humans has increased substantially. Here, we review both antitumor and tolerogenic DC responses in cancer and discuss lineage-specific contributions by their functionally specialized subsets, including the conventional DC (cDC) subsets cDC1 and cDC2, the newly described DC3, and the plasmacytoid DCs (pDCs), focusing on the human setting. In addition, we review the lineage-unrestricted “mature DCs enriched in immunoregulatory molecules” (mregDC) state recently described across different human tumors.
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