任务(项目管理)
神经科学
纹状体
认知
控制(管理)
心理学
间接运动途径
内部模型
电动机控制
直接运动途径
认知心理学
计算机科学
多巴胺
人工智能
管理
经济
作者
Scott S. Bolkan,Iris R. Stone,Lucas Pinto,Zoe C. Ashwood,Jorge M. Iravedra Garcia,Alison L. Herman,Priyanka Singh,Akhil Bandi,Julia Cox,Christopher A. Zimmerman,Jounhong Ryan Cho,Ben Engelhard,Jonathan W. Pillow,Ilana B. Witten
标识
DOI:10.1038/s41593-022-01021-9
摘要
A classic view of the striatum holds that activity in direct and indirect pathways oppositely modulates motor output. Whether this involves direct control of movement, or reflects a cognitive process underlying movement, remains unresolved. Here we find that strong, opponent control of behavior by the two pathways of the dorsomedial striatum depends on the cognitive requirements of a task. Furthermore, a latent state model (a hidden Markov model with generalized linear model observations) reveals that—even within a single task—the contribution of the two pathways to behavior is state dependent. Specifically, the two pathways have large contributions in one of two states associated with a strategy of evidence accumulation, compared to a state associated with a strategy of repeating previous choices. Thus, both the demands imposed by a task, as well as the internal state of mice when performing a task, determine whether dorsomedial striatum pathways provide strong and opponent control of behavior. The authors use virtual reality tasks and a latent state modeling approach to demonstrate that the opposing control of behavior by striatal pathways is dependent on both task demands and changes in internal state.
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