Back-propagating action potentials in pyramidal neurons: a putative signaling mechanism for the induction of Hebbian synaptic plasticity.

神经科学 突触后电位 去极化 突触可塑性 非突触性可塑性 突触 抑制性突触后电位 树枝状尖峰 赫比理论 突触电位 兴奋性突触后电位 轴突 生物 变质塑性 生物物理学 受体 计算机科学 生物化学 机器学习 人工神经网络
作者
Costa M. Colbert
出处
期刊:PubMed 卷期号:19 (3-4): 199-211 被引量:12
链接
标识
摘要

A hallmark of synaptic plasticity is the associative, or Hebbian, nature of its induction. By associative, we mean that the timing relationships between activity of the pre- and postsynaptic elements of a synapse determine whether synaptic strengths are modified. lt is well-established that associativity results, in large part, from the dual requirements for activation of the N-methyl-D-aspartate receptor-ionophore, namely presynaptic neurotransmitter release and postsynaptic depolarization. However, the specific dendritic events that provide the postsynaptic depolarization have been relatively unexplored. Increasing evidence suggests that back-propagating (i.e., antidromic) Na(+) action potentials provide the necessary postsynaptic depolarization to allow induction of associative synaptic plasticities. In hippocampal CAI and neocortical layer V pyramidal neurons, these action potentials provide much greater levels of dendritic depolarization than would be expected from synaptic currents alone. Moreover, they provide a relatively brief and synchronous depolarization throughout the dendritic arbor, allowing timing relationships to more directly reflect pre- and postsynaptic cell firing. Interestingly, certain properties of the back-propagating actions potentials differ from axonal or somatic action potentials in ways that seem to reflect their function. For example, the all-or-none property of action potential amplitude does not hold in the dendrites. In this review we discuss the back-propagating action potential as a dendritic signal that provides information to synapses about the firing state of the postsynaptic neuron. First, we consider the evidence that action potentials propagate back from the axon. Second, we describe the characteristics of the back-propagating action potential in terms of interactions of its underlying ionic currents. Third, we describe how these properties contribute to the timing aspects of the induction of long-term potentiation. Finally, we discuss modulation of the underlying ion channels by neurotransmitter systems and other agents and speculate on their roles in learning and memory.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
冰千蕙发布了新的文献求助10
刚刚
MZ发布了新的文献求助10
1秒前
时尚战斗机应助善良的人采纳,获得10
1秒前
2秒前
领导范儿应助满anna采纳,获得10
2秒前
秦玉蓉发布了新的文献求助10
3秒前
4秒前
必中完成签到,获得积分20
5秒前
英姑应助wang采纳,获得10
6秒前
所所应助ylver采纳,获得50
6秒前
reirei应助sun_lin采纳,获得10
7秒前
眼睛大雨筠应助云ch采纳,获得60
8秒前
热心市民小红花应助Cici采纳,获得10
10秒前
秦玉蓉完成签到,获得积分10
10秒前
传奇3应助微微采纳,获得10
11秒前
11秒前
美丽灵活呜呜豹完成签到,获得积分10
13秒前
香蕉觅云应助CQ采纳,获得10
15秒前
15秒前
Salut完成签到,获得积分10
16秒前
量子星尘发布了新的文献求助10
16秒前
传奇3应助gu采纳,获得10
16秒前
17秒前
17秒前
默默安双完成签到 ,获得积分20
19秒前
ZXCVB发布了新的文献求助10
19秒前
pipi发布了新的文献求助10
20秒前
曹璐瑶发布了新的文献求助10
20秒前
22秒前
里德完成签到 ,获得积分10
22秒前
qq发布了新的文献求助10
22秒前
23秒前
23秒前
JamesPei应助pipi采纳,获得10
24秒前
24秒前
科研通AI2S应助秋不落棠采纳,获得10
24秒前
YamDaamCaa应助微微采纳,获得30
25秒前
26秒前
27秒前
CQ发布了新的文献求助10
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969940
求助须知:如何正确求助?哪些是违规求助? 3514642
关于积分的说明 11175298
捐赠科研通 3249947
什么是DOI,文献DOI怎么找? 1795178
邀请新用户注册赠送积分活动 875617
科研通“疑难数据库(出版商)”最低求助积分说明 804891