肠道菌群
单糖
益生元
化学
盲肠
生物化学
乳酸菌
多糖
低聚糖
细菌
双歧杆菌
半乳糖
食品科学
生物
发酵
遗传学
生态学
作者
Lei Wang,Rui Cheng,Xiaqing Sun,Jing Wang,Wenhao Ge,Yunxia Yang,Yan Gao,Zhao Ding,Junhao Liu,Jianfa Zhang
标识
DOI:10.1021/acs.jafc.0c07783
摘要
In relation to available polysaccharides, oligosaccharides have a low molecular weight, less viscosity, and complete water solubility. These properties endow oligosaccharides with significant biological properties including the microbiota regulation ability. In this study, a homogeneous oligooctasaccharide, riclinoctaose, was biosynthesized from succinylglycan riclin by enzymatic degradation. Monosaccharide composition, Fourier-transform infrared, electrospray ionization mass spectrometry, and nuclear magnetic resonance spectrometry analysis indicated that riclinoctaose is an oligooctasaccharide consisting of one galactose and seven glucose residues, with a pyruvate group linked to the terminal glucose residue. The effects of dietary riclinoctaose on the gut microbiota of mice were evaluated. We found that the dietary riclinoctaose significantly altered intestinal microbiota with the increased growth of beneficial intestinal bacteria including Bifidobacteria and Lactobacillus and decreased the abundance of pernicious bacteria such as Gammaproteobacteria. The level of short-chain fatty acids (SCFAs) was significantly elevated in the riclinoctaose cecum. Our results suggested that riclinoctaose as a prebiotic may have a great potential application in functional foods.
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