化学
硝基苯
胺化
烷基
三苯基膦
硼酸
光化学
组合化学
还原胺化
催化作用
芳基
有机化学
药物化学
作者
Kartic Manna,Tapan Ganguly,Sujoy Baitalik,Ranjan Jana
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-10-13
卷期号:23 (21): 8634-8639
被引量:21
标识
DOI:10.1021/acs.orglett.1c03343
摘要
We present here a metal-free, visible-light- and triphenylphosphine-mediated intermolecular, reductive amination between nitroarenes and boronic acids at ambient temperature without any photocatalyst. Mechanistically, a slow reduction of nitroarenes to a nitroso and, finally, a nitrene intermediate occurs that leads to the amination product with concomitant 1,2-aryl/-alkyl migration from a boronate complex. A wide range of nitroarenes underwent C-N coupling with aryl-/alkylboronic acids providing high yields.
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